Message from the Director

The Research Institute for Biomedical Sciences has been established in 1989 as a platform for collaborative researches among different disciplines of science and biomedical companies. Biomaterial science and biological and pharmaceutical sciences were major areas of activity at the beginning.
Almost 25 year ago, the Institute was dramatically reorganized to be a research institute for immunology science and gradually modified to cover broader area of biological sciences including neurology, developmental biology, aging and oncology.
In 2012, eventually the institute was renamed to Research Institute for Biomedical Sciences and started to cover clinical research and innovation of medical equipment in collaboration with research in engineering and hospitals of major medical schools and National Cancer Center(NCC) and a cross-appointed cooperative research laboratory to develop innovative medical technologies and equipment is established by NCC and Our University in Kashiwa Campus of NCC.

Main aim of our institute is basic understanding of life itself and we make every endeavor to this end. In addition, as researcher of biomedical science, we believe that our science has to be filled with admiration and awe of life and it also must be in full of affection to patients who are suffering from illness.

HIGAMI Yoshikazu

Director, Research Institute for Biomedical Sciences
Profile

Division Groups

Division of Immunology and Allergy
This division focuses on the development and function of the immune system. We are working on the mechanisms of differentiation,regeneration and tumorigenesis of the immune cells. These studies will lead to the development of the novel regenerative immunotherapy.
Division of Cancer Cell Biology
Cancer cells arise from normal cells through genetic insults, and are hallmarked by overgrowth, the resistance to extracellular stress and invasive/metastatic abilities. In addition, the tumor tissue is an elaborate network where cancer cells closely interact with immune cells, fibroblasts and endothelial cells, etc. This research division aims to uncover the nature of cell growth, differentiation, genetic and metabolic regulation of the cells in such abnormal-normal cell society.
Division of Biosignaling
This division focuses on understanding the molecular mechanism of dynamic and complex biological systems such as brain and immune system by using advanced imaging techniques, biophysical tools, and system-biological approach. The elucidation of molecular mechanisms underlying axon outgrowth/regeneration, neuronal homeostasis, peptide recognition by T cell receptors will provide clues to develop clinical applications for a variety of diseases.
Division of Cell Fate Regulation
The mission of our division is to understand the alteration and regulation of life & cell-fate by investigating them at each of multiple chronological stages, and at each scales between biomolecules, genome, RNA, protein, cell, tissue, and a living organism.
Division of Molecular Pathology
This research division seeks to understand a picture of the homeostatic regulation by cytokines. Aberrationsofthe cytokine system is known to tightly associate with various immunological disorders. Our ultimate goal istounderstand cytokine biology to control immune responses. This can be a powerful way to control disease.Therefore,this division pursues research investigating the mechanisms underlying the cytokine related pathogenicsituations,including infectious diseases, autoimmune diseases, and allergy.
Division of Molecular Regulation of Inflammatory and Immune Diseases
Clinical development of therapeutics based on basic research for intractable inflammatory and immunediseases,particularly chronic inflammation-associated organ fibrosis and cancer.
Division of Experimental Animal Immunology
This new division was established in the 2008 academic year to promote teaching and research in the fieldoflaboratory animal science. The division studies animals with modified genes, specifically genes involved inthedifferentiation and functioning of immune cells and hemopoietic cells, in order to clarify the roles ofthosemolecules in diseases.
Division of Biomedical Technology
Our mission is to develop innovative medical devices "hyper-assisted medical devices" that assist medical treatment with capabilities beyond human skills. To success the mission, our division promotes collaborate research with physicians in the NEXT Medical Device Development Center, The National Cancer Center Hospital East.
Divison of Integrated Research
Our mission is to promote cross-disciplinary and advanced collaborative research in cooperation with other faculties in our university, other research institutions, and industry.

List of Faculty Members

Director HIGAMI Yoshikazu
Division of
Immunobiology and Allergy
Professor IKAWA Tomokatsu
Assistant Professor

SHIGEHIRO Tsukasa

Associate Professor
(Concurrent faculty)
NAKAMURA Yoshikazu
Division of
Cancer Cell Biology
Professor KITAMURA Daisuke
Junior Associate Professor KON Shunsuke
Junior Associate Professor HANIUDA Kei
Professor
(Concurrent faculty)
AOKI Shin
Junior Associate Professor
(Concurrent faculty)
HARADA Yohsuke
Division of
Biosignaling
Professor NAKAMURA Takeshi
Associate Professor KOZONO Haruo
Assistant Professor

KOINUMA Shingo

Professor
(Concurrent faculty)
WADA Naoyuki
Division of
Cell Fate Regulation
Professor GOITSUKA Ryo
Junior Associate Professor SAKURAI Masayuki
Assistant Professor

OKAZAKI Shogo

Assistant Professor OKADA Shunpei
Professor
(Concurrent faculty)
HIGAMI Yoshikazu
Professor
(Concurrent faculty)
WADA Takeshi
Professor
(Concurrent faculty)
TORIGOE Hidetaka
Division of
Molecular Pathology
Professor KUBO Masato
Associate Professor NAKANO Naoko
Professor
(Concurrent faculty)
MIYAZAKI Satoru
Associate Professor
(Concurrent faculty)
MASAIKE Tomoko
Division of
Molecular Regulation of
Inflammatory and
Immune Diseases
Professor

MATSUSHIMA Kouji

Associate Professor UEHA Satoshi
Junior Associate Professor

TERASHIMA Yuya

Assistant Professor SHICHINO Shigeyuki
Assistant Professor

CHANDRASEKAR Balachandran

Division of Experimental
Animal Immunology
Professor IWAKURA Yoichiro
Assistant Professor CHUNG Soo Hyun
Division of
Biomedical Technology
Professor
(Concurrent faculty)
TAKEMURA Hiroshi
Professor
(Concurrent faculty)
SOGA Kohei
Professor
(Concurrent faculty)
HAYASE Masanori
Professor
(Concurrent faculty)
YASUMORI Atsuo
Assistant Professor

TAKAMATSU Toshihiro

Assistant Professor

DOAN Thi Kim Dung

Divison of
Integrated Research
Professor HIGAMI Yoshikazu
Junior Associate Professor OGAWA Shuhei
Shared equipment Technical Assistant

HARA Yasushi