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BRAP2 Inhibits the Ras/Raf/MEK and PI3K/Akt Pathways in Leukemia Cells, Thereby Inducing Apoptosis and Inhibiting Cell Growth
[ 全著者名 ] Hiroharu SAKAI, Isamu SHIINA, Takahisa SHINOMIYA, Yukitoshi NAGAHARA
[ 掲載誌名 ] Experimental and Therapeutic Medicine
[ 掲載年月 ] 2021年 3月
[ 著作区分 ] レフェリー付学術論文(外国語)
4-(Dimethylamino)pyridine N-Oxide-Catalyzed Macrolactamization Using 2-Methyl-6-nitrobenzoic Anhydride in the Synthesis of the Depsipeptidic Analogue of FE399
[ 全著者名 ] Takayuki TONOI, Takehiko INOHANA, Ryo KAWAHARA, Teruyuki SATO, Miyuki IKEDA, Miku AKUTSU, Takatsugu MURATA, Isamu SHIINA
[ 掲載誌名 ] ACS Omega
[ 掲載年月 ] 2021年 2月
[ 著作区分 ] レフェリー付学術論文(外国語)
Total Synthesis of the Antitumor Depsipeptide FE399 and Its S-Benzyl Derivative: A Macrolactamization Approach
[ 全著者名 ] Takayuki TONOI, Miyuki IKEDA, Teruyuki SATO, Takehiko INOHANA, Ryo KAWAHARA, Takatsugu MURATA, Isamu SHIINA
[ 掲載誌名 ] EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
[ 掲載年月 ] 2020年 8月
[ 著作区分 ] レフェリー付学術論文(外国語)
Kinetic Resolution of Racemic 2-Hydroxyarylketones by Asymmetric Esterification: Investigation of the Influence of the Co-Base on the Selectivity
[ 全著者名 ] Takatsugu MURATA, Kengo FUTAMI, Ryo ISHIKAWA, Keisuke ONO, Kenya NAKATA, Isamu SHIINA
[ 掲載誌名 ] ASIAN J ORG CHEM
[ 掲載年月 ] 2020年 2月
[ 著作区分 ] レフェリー付学術論文(外国語)
Total Synthesis and Antimicrobial Evaluation of 23-Demethyleushearilide and Extensive Antimicrobial Evaluation of All Synthetic Stereoisomers of (16Z,20E)-Eushearilide and (16E,20E)-Eushearilide
[ 全著者名 ] Takayuki TONOI, Takehiko INOHANA, Teruyuki SATO, Yuuki NODA, Miyuki IKEDA, Miku AKUTSU, Takatsugu MURATA, Yutaro MAEKAWA, Anna TANAKA, Rio SEKI, Misako OHKUSU, Katsuhiko KAMEI, Naruhiko ISHIWADA, Isamu SHIINA
[ 掲載誌名 ] MOLECULES
[ 掲載年月 ] 2019年 9月
[ 著作区分 ] レフェリー付学術論文(外国語)
N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells
[ 全著者名 ] Yuuki OBATA, Yasushi HARA, Isamu SHIINA, Takatsugu MURATA, Yasutaka TASAKI, Kyohei SUZUKI, Keiichi ITO, Shou TSUGAWA, Kouhei YAMAWAKI, Tsuyoshi TAKAHASHI, Koji OKAMOTO, Toshirou NISHIDA, Ryo ABE
[ 掲載誌名 ] CELL COMMUN SIGNAL
[ 掲載年月 ] 2019年 9月
[ 著作区分 ] レフェリー付学術論文(外国語)
DIASTEREO–/ENANTIOSELECTIVE DIELS–ALDER SYNTHESIS OF 14β-HYDROXYSTEROID SCAFFOLDS: A COMBINED EXPERIMENTAL AND DFT STUDY
[ 全著者名 ] Clovis Peter, Philippe Geoffroy, Takatsugu Murata, Takayuki Tonoi, Isamu Shiina, Michel Miesch
[ 掲載誌名 ] HETEROCYCLES
[ 掲載年月 ] 2019年 6月
[ 著作区分 ] レフェリー付学術論文(外国語)
Novel Ridaifen-B Structure Analog Induces Apoptosis and Autophagy Depending on Pyrrolidine Side Chain
[ 全著者名 ] Takumi Iwasawa, Takahisa Shinomiya, Nozomi Ota, Natsumi Shibata, Kenya Nakata, Isamu Shiina, Yukitoshi Nagahara
[ 掲載誌名 ] BIOLOGICAL & PHARMACEUTICAL BULLETIN
[ 掲載年月 ] 2019年 3月
[ 著作区分 ] レフェリー付学術論文(外国語)
Total Synthesis of Violaceoid A and (−)- and (+)-Violaceoid B
[ 全著者名 ] Takatsugu MURATA, Teppei KUBOKI, Ryo ISHIKAWA, Takahiro SAITO, Shotaro TAGUCHI, Kazuma TAKEUCHI, Emiko HATANO, Motoyuki SHIMONAKA, Isamu SHIINA
[ 掲載誌名 ] JOURNAL OF NATURAL PRODUCTS
[ 掲載年月 ] 2018年 11月
[ 著作区分 ] レフェリー付学術論文(外国語)
Kinetic Resolution of Racemic 2-Hydroxyamides Using a Diphenylacetyl Component as an Acyl Source and a Chiral Acyl-Transfer Catalyst
[ 全著者名 ] Takatsugu MURATA, Tatsuya KAWANISHI, Akihiro SEKIGUCHI, Ryo ISHIKAWA, Keisuke ONO, Kenya NAKATA, Isamu SHIINA
[ 掲載誌名 ] MOLECULES
[ 掲載年月 ] 2018年 8月
[ 著作区分 ] レフェリー付学術論文(外国語)
Total Synthesis and Antimicrobial Activities of All Stereoisomers of (16Z,20E)‐Eushearilide and (16E,20E)‐Eushearilide
[ 全著者名 ] Takayuki TONOI, Takehiko INOHANA, Teruyuki SATO, Tomoki YOSHIDA, Isamu SHIINA
[ 掲載誌名 ] JOURNAL OF ORGANIC CHEMISTRY
[ 掲載年月 ] 2018年 8月
[ 著作区分 ] レフェリー付学術論文(外国語)
Anti‐proliferative Effect of Ridaifen‐B on Hepatoma Cells
[ 全著者名 ] Go HASEGAWA, Kotomi AKATSUKA, Keita HIRUMA, Kayako SUDA, Yumiko YOKOE, Akihito MIZUSAWA, Nozomi OTA, Natsumi SHIBATA, Kaho TSUCHIYA, Moyuru HAYASHI, Isamu SHIINA, Motoyuki SHIMONAKA
[ 掲載誌名 ] Biomedical Reports
[ 掲載年月 ] 2018年 6月
[ 著作区分 ] レフェリー付学術論文(外国語)
Asymmetric Total Synthesis of (+)-Coprophilin
[ 全著者名 ] Isamu SHIINA, Yuma UMEZAKI, Takatsugu MURATA, Kyohei SUZUKI, Takayuki TONOI
[ 掲載誌名 ] SYNTHESIS-STUTTGART
[ 掲載年月 ] 2018年 3月
[ 著作区分 ] レフェリー付学術論文(外国語)
Oncogenic Kit signalling on the Golgi is suppressed by blocking secretory trafficking with M-COPA in gastrointestinal stromal tumours
[ 全著者名 ] Yuuki Obata, Keita Horikawa, Isamu Shiina, Tsuyoshi Takahashi, Takatsugu Murata, Yasutaka Tasaki, Kyohei Suzuki, Keita Yonekura, Hiroyasu Esumi, Toshirou Nishida, Ryo Abe
[ 掲載誌名 ] CANCER LETTERS
[ 掲載年月 ] 2018年 2月
[ 著作区分 ] レフェリー付学術論文(外国語)
Ridaifen-F Conjugated with Cell-Penetrating Peptides Inhibits Intracellular Proteasome Activities and Induces Drug-Resistant Cell Death
[ 全著者名 ] Makoto Tanaka, Yunhao Zhu, Masafumi Shionyu, Nozomi Ota, Natsumi Shibata, Chihiro Watanabe, Akihito Mizusawa, Ryuzo Sasaki, Tamio Mizukami, Isamu Shiina, Makoto Hasegawa
[ 掲載誌名 ] EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
[ 掲載年月 ] 2018年 2月
[ 著作区分 ] レフェリー付学術論文(外国語)
Targeting the Golgi apparatus to overcome acquired resistance of non-small cell lung cancer cells to EGFR tyrosine kinase inhibitors
[ 全著者名 ] Yoshimi Ohashi, Mutsumi Okamura, Ryohei Katayama, Siyang Fang, Saki Tsutsui, Akinobu Akatsuka, Mingde Shan, Hyeong-Wook Choi, Naoya Fujita, Kentaro Yoshimatsu, Isamu Shiina, Takao Yamori, Shingo Dan
[ 掲載誌名 ] Oncotarget
[ 掲載年月 ] 2018年 1月
[ 著作区分 ] レフェリー付学術論文(外国語)
Family-wide Analysis of the Inhibition of Arf Guanine Nucleotide Exchange Factors with Small Molecules: Evidence of Unique Inhibitory Profiles
[ 全著者名 ] Sarah BENABDI, François PEUROIS, Agata NAWROTEK, Jahnavi CHIKIREDDY, Tatiana CAÑEQUE, Takao YAMORI, Isamu SHIINA, Yoshimi OHASHI, Shingo DAN, Raphaël RODRIGUEZ, Jacqueline CHERFILS, Mahel ZEGHOUF
[ 掲載誌名 ] BIOCHEMISTRY
[ 掲載年月 ] 2017年 9月
[ 著作区分 ] レフェリー付学術論文(外国語)
Asymmetric Total Synthesis of (−)-Astakolactin and Confirmation of Its Stereostructure
[ 全著者名 ] Takayuki TONOI, Yutaka YOSHINAGA, Moe FUJISHIRO, Keisuke MAMEDA, Takashi KATO, Kentaro SHIBAMOTO, Isamu SHIINA
[ 掲載誌名 ] JOURNAL OF NATURAL PRODUCTS
[ 掲載年月 ] 2017年 8月
[ 著作区分 ] レフェリー付学術論文(外国語)
Acylative Kinetic Resolution of Racemic Aromatic β-Hydroxy Esters Catalyzed by Chiral Nucleophilic N-(1-Arylethyl)benzoguanidines
[ 全著者名 ] Akira Yamada, Isamu SHIINA, and Kenya NAKATA
[ 掲載誌名 ] TETRAHEDRON-ASYMMETRY
[ 掲載年月 ] 2017年 4月
[ 著作区分 ] レフェリー付学術論文(外国語)
M-COPA Suppresses Endolysosomal Kit-Akt Oncogenic Signalling through Inhibiting the Secretory Pathway in Neoplastic Mast Cells
[ 全著者名 ] Yasushi Hara, Yuuki Obata, Keita Horikawa, Yasutaka Tasaki, Kyohei Suzuki, Takatsugu Murata, Isamu Shiina, and Ryo Abe
[ 掲載誌名 ] PLoS One
[ 掲載年月 ] 2017年 4月
[ 著作区分 ] レフェリー付学術論文(外国語)
EXPEDITIOUS SYNTHESIS OF CARBOXYLIC ESTERS AND HIGH-YIELDING MACROLACTONES USING TRIFLUOROMETHYL-SUBSTITUTED BENZOIC ANHYDRIDES WITH 4-(DIMETHYLAMINO)PYRIDINE: AN EVALUATION OF THE REACTIVITIES OF AROMATIC ACID ANHYDRIDES AS DEHYDRATION REAGENTS COMPARED WITH 2-METHYL-6-NITROBENZOIC ANHYDRIDE
[ 全著者名 ] Isamu SHIINA and Takayuki TONOI
[ 掲載誌名 ] HETEROCYCLES
[ 掲載年月 ] 2017年 2月
[ 著作区分 ] レフェリー付学術論文(外国語)
KINETIC RESOLUTION OF RACEMIC 2-HYDROXYACETALS BY ASYMMETRIC ESTERIFICATION USING A MIXED ANHYDRIDE PROTOCOL
[ 全著者名 ] Kenya Nakata, Eri Tokumaru, Takahiro Saitoh, Takayoshi Nakahara, Keisuke Ono, Takatsugu Murata, and Isamu Shiina
[ 掲載誌名 ] HETEROCYCLES
[ 掲載年月 ] 2016年 10月
[ 著作区分 ] レフェリー付学術論文(外国語)
Enantioselective Total Synthesis of Naturally Occurring Eushearilide and Evaluation of Its Antifungal Activity
[ 全著者名 ] Takayuki TONOI, Ryo KAWAHARA, Takehiko INOHANA, and Isamu SHIINA
[ 掲載誌名 ] JOURNAL OF ANTIBIOTICS
[ 掲載年月 ] 2016年 9月
[ 著作区分 ] レフェリー付学術論文(外国語)
M-COPA, a Novel Golgi System Disruptor, Suppresses Apoptosis Induced by Shiga Toxin
[ 全著者名 ] Takayuki HATTORI, Miho WATANABE-TAKAHASHI, Isamu SHIINA, Yoshimi OHASHI, Shingo DAN, Kiyotaka NISHIKAWA, Takao YAMORI, and Mikihiko NAITO
[ 掲載誌名 ] GENES TO CELLS
[ 掲載年月 ] 2016年 8月
[ 著作区分 ] レフェリー付学術論文(外国語)
M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers
[ 全著者名 ] Yoshimi OHASHI, Mutsumi OKAMURA, Asaka HIROSAWA, Naomi TAMAKI, Akinobu AKATSUKA, Kuo-Ming WU, Hyeong-Wook CHOI, Kentaro YOSHIMATSU, Isamu SHIINA, Takao YAMORI, and Shingo DAN
[ 掲載誌名 ] CANCER RESEARCH
[ 掲載年月 ] 2016年 7月
[ 著作区分 ] レフェリー付学術論文(外国語)
不斉エステル化反応を用いたキラル医薬品の合成―抗炎症剤および抗肥満薬の製造を例として― Synthesis of Chiral Pharmaceutical Drugs by Using Asymmetric Esterification―Application for the Production of Non-Steroidal Anti-Inflammatory Drugs; NSAIDs, and Tetrahydrolipstatin; THL―
[ 全著者名 ] 中田健也、殿井貴之、椎名 勇
[ 掲載誌名 ] 月刊ファインケミカル
[ 掲載年月 ] 2016年 2月
[ 著作区分 ] レフェリー付学術論文(日本語)
Nonenzymatic, Enantioconvergent Dynamic Kinetic Resolution (DKR) of Racemic 2-(1H-Pyrrol-1-yl)alkanoic Acids as α-Amino Acid Equivalents
[ 全著者名 ] Eri TOKUMARU, Atsushi TENGEIJI, Takayoshi NAKAHARA, and Isamu SHIINA
[ 掲載誌名 ] CHEMISTRY LETTERS
[ 掲載年月 ] 2015年 12月
[ 著作区分 ] レフェリー付学術論文(外国語)
Ridaifen G, tamoxifen analog, is a potent anticancer drug working through a combinatorial association with multiple cellular factors
[ 全著者名 ] Kentaro IKEDA, Shinji KAMISUKI, Shoko UETAKE, Akihito MIZUSAWA, Nozomi OTA, Tatsuki SASAKI, Senko TSUKUDA, Tomoe KUSAYANAGI, Yoichi TAKAKUSAGI, Kengo MOROHASHI, Takao YAMORI, Shingo DAN, Isamu SHIINA, and Fumio SUGAWARA
[ 掲載誌名 ] BIOORGANIC & MEDICINAL CHEMISTRY
[ 掲載年月 ] 2015年 8月
[ 著作区分 ] レフェリー付学術論文(外国語)
Total Synthesis of (3R,16E,20E,23R)-(-)-Eushearilide and Structural Determination of Naturally Occurring Eushearilide
[ 全著者名 ] Takayuki TONOI, Ryo KAWAHARA, Yutaka YOSHINAGA, Takehiko INOHANA, Keiko FUJIMORI, and Isamu SHIINA
[ 掲載誌名 ] TETRAHEDRON LETTERS
[ 掲載年月 ] 2015年 3月
[ 著作区分 ] レフェリー付学術論文(外国語)
Total Synthesis of the Proposed Structure of Astakolactin
[ 全著者名 ] Takayuki TONOI, Keisuke MAMEDA, Moe FUJISHIRO, Yutaka YOSHINAGA, and Isamu SHIINA
[ 掲載誌名 ] Beilstein Journal of Organic Chemistry
[ 掲載年月 ] 2014年 10月
[ 著作区分 ] レフェリー付学術論文(外国語)
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