東京理科大学　研究者情報データベース　

Biological Systemsのシラバス情報

科目名称 Course title(Japanese)	Biological Systems	科目番号 Course number	03BIMEB506
科目名称（英語） Course title(English)	Biological Systems Biological Systems
授業名称 Class name	Biological Systems

教員名	櫻井　雅之，久保　允人，北村　大介，小園　晴生，水田　龍信，後飯塚　僚，小川　修平，中村　岳史，岩倉　洋一郎，伊川　友活，昆　俊亮，上羽　悟史，寺島　裕也，波江野　洋
Instructor	Masayuki Sakurai and other teachers.

開講年度学期	2022年度後期
Year/Semester	2022 First Semester

曜日時限	水曜1限
Class hours	Sunday 6th Period

開講学科 Department	Graduate School of Biological Sciences, Department of Biological Sciences
外国語のみの科目（使用言語） Course in only foreign languages (languages)	English Only

単位 Course credit	2.0	授業の主な実施形態 Main class format	On-site class

概要 Descriptions	Living organisms respond and influence on stimuli and information from the outside world, and cooperation of various elementary processes such as cell differentiation, proliferation, and cell death occur. Consequently, maintenance and regeneration of tissues and organs are continually occurred based on homeostatic regulation. There are systems as individual cells and dynamic systems that should be succeeded to next generations. In this course, students can understand the basics of the life system.
目的 Objectives	In this course, students will understand the basic knowledge of life system such as gene, genome, transcription, the epigenetic control, structure and function of the protein, and signal transduction mechanism related to cell function. In addition, students will obtain basic and public knowledge such as the onset mechanisms of diseases caused by the dysregulation of homeostasis, and the development of new therapeutic strategies. This is the subject that corresponds to the Diploma Policy "It is possible to understand the cutting-edge knowledge of the life sciences systematically, and possible to accumulate experiences about the various issues related to life sciences" in the Graduate School.
到達目標 Outcomes	１）Students will be able to outline the repair and maintenance mechanism of the genome, and the gene expression control including epigenetics. ２）Students will be able to outline the basic structure and the high-order structure formation of a protein, and the association with the function. ３）Students can outline the established mechanism of the hematopoietic system and immune system, with taking the dynamic system as an example, which is established by the cell-to-cell communication. ４）Students will be able to outline the pathological expression mechanism associated with the collapse of the system and the development and clinical application of new therapeutic strategies “with taking the human genome and cancer treatment as examples”.
履修上の注意 Course notes prerequisites	Note that this course is almost equivalent context to “生命システム論” on Wednesday 5th period in the 2022 First Semester. We recommend to take 生命システム論" instead of this course unless you are not able to understand Japanese at all. "生命システム論" is basically performed in English. *Unless an international student who can not understand Japanese at all selects this course, We will not hold it. Once it is determined to be held, any students can take the course. In taking this course, you would better to have basic knowledge about biochemistry, molecular genetics, cell biology, biophysical chemistry. Your active participation in the lecture, especially in the discussion, will be expected with your own preparation as well as review before and after the lecture.

アクティブ・ラーニング科目 Teaching type（Active Learning）
課題に対する作文 Essay	○	小テストの実施 Quiz type test	○
ディベート・ディスカッション Debate/Discussion	○	グループワーク Group work	-
プレゼンテーション Presentation	-	反転授業 Flipped classroom	-
その他（自由記述） Other（Describe）	-

準備学習・復習 Preparation and review	The content of lecture will be uploaded on the CLASS system before the lecture for your preparation and review.
成績評価方法 Performance grading policy	To be evaluated by internal report or test (80%) and positiveness of participation in discussion (20%).
学修成果の評価 Evaluation of academic achievement	・S：到達目標を十分に達成し、極めて優秀な成果を収めている・A：到達目標を十分に達成している・B：到達目標を達成している・C：到達目標を最低限達成している・D：到達目標を達成していない・-：学修成果の評価を判断する要件を欠格している・S：Achieved outcomes, excellent result ・A：Achieved outcomes, good result ・B：Achieved outcomes ・C：Minimally achieved outcomes ・D：Did not achieve outcomes ・-：Failed to meet even the minimal requirements for evaluation
教科書 Textbooks/Readings	・教科書を使用する場合は、MyKiTS(教科書販売サイト)から検索・購入可能ですので以下のURLにアクセスしてください。 https://gomykits.kinokuniya.co.jp/tokyorika/ 　・Search and purchase the necessary textbooks from MyKiTS (textbook sales site) with the link below. https://gomykits.kinokuniya.co.jp/tokyorika/
参考書・その他資料 Reference and other materials	The followings are recommended to read. Molecular Biology of the Cell (6th Edition), B. Alberts et al. （Garland Science） Molecular Biology of the Gene (7th Edition), J.D. Watson et al. (Benjamin Cummings) Janeway's Immunobiology (8th edition), K. Murphy (Garland Science) Cellular and Molecular Immunology (8th edition), A.K. Abbas et al (Saunders)

授業計画 Class plan	1●Structure and function of the gene: KITAMURA Daisuke --Students will understand the structure and function of genes in the genome and the major genetic engineering technology. 2●Gene recombination: MIZUTA Ryushin --Students will understand the mechanism of genetic information reorganization by cutting and repairing DNA. Further, Students will understand the physiological significance of that mechanism. 3●High dimensional structure and Function of Protein: KOZONO Haruo --Higher-order structure is essential for protein to exert the function. Students will understand the molecular mechanism of antigen recognition with focusing on higher-order structure of the protein to be expressed in the immune system. 4●New imaging technology for life system analysis: NAKANURA Takeshi --State-of-the-art imaging technology (two-photon excitation microscope, super-resolution microscope, FRET imaging, etc.) is effective for analyzing the life system from molecules to cells and whole animals. Students will be able to understand the fundamentals of the microscope and the outline of these imaging techniques. 5●Epigenetic control in developmental biology: IKAWA Tomokatsu In differentiation process of stem cells, epigenetic control is necessary switch to read necessary information on the genomic DNA. Students will understand the molecular mechanism of epigenetic regulation, including DNA methylation and histone modification, in cell maintenance and differentiation. 6●Gene regulation and advanced techniques by RNA editing & modifications: SAKURAI Masayuki RNA transcribed from DNA are known to be composed of four bases; A, G, C and U. However, RNA bases are further modified or edited enzymatically such as inosine produced by deamination of A. Students will understand the mechanisms of RNA editing & modifications known as “epitranscriptomics” and the recent applied techniques for the regulation of gene expression and the cure for diseases. 7●Stem cell biology: GOISUKA Ryo --Tissue stem cells represented by hematopoietic stem cells are important groups of cells to maintain homeostasis of the living organism. Students will understand the development and maintenance of stem cells, and the relationship of stem cells and the microenvironment. 8●Lineage determination and development of the immune system: NAKANO Naoko --Students need to understand the molecular mechanism, that is, immune system cells with different function differentiated from hematopoietic stem cells, and lineage decision is taken place. 9●Cell competition and carcinogenesis: KON Shunsuke --This class starts with general remarks on oncogenesis and tumor progression, and mainly deals with cell competition between normal and transformed epithelial cells.　 10●Animal Disease Models: IWAKURA Yoichiro --The homeostasis of our body is maintained by the collaboration of many genes as a system. In this lecture, you will learn how cytokines and innate immune receptors are involved in the development of diseases using gene manipulated mouse models. 11●Cytokines and disease; New insight in allergy: KUBO Masato --Students will understand the mechanism of diseases caused by the dysregulation of cytokines. Also, students will understand the current status of medical care with biologic targeting cytokine function. Moreover, students will understand the molecular basis of many allergic diseases. 12●Regulation of inflammation and immunity by cytokines and chemokines:TERASHIMA Yuya --Most of the human diseases are inflammatory and immune diseases. Tissue infiltration of specific types of leukocytes underlies the inflammatory and immune responses to invasive stress. In this lecture, students will learn basic mechanisms of the inflammatory and immune responses regulated by cytokines and chemokines, and understand the bases for disease treatments which target cytokines and chemokines. 13●Acquired immune response and signaling: OGAWA Syuuhei --Students will understand what molecule is activated and transmitted, when the signal is transmitted from antigen receptor, auxiliary signal molecule, and the cytokine receptor. Students will understand what kind of role the activation of each signaling pathway perform for the activation and expression function in T cells and B cells 14●Data science and mathematical modeling in life sciences: HAENO Hiroshi --Large datasets about DNA mutations, gene expression, and so on have become easily available due to the development of measurement technology. In this lecture, students will learn how to analyze such big data, understand the evolutionary dynamics of tumor progression from initiation to diagnosis, and acquire basic knowledge about immunity as a defense mechanism against non-self organisms. 15●Population dynamics of macrophages and dendritic cells in vivo: UEHA Satoshi --Macrophages and dendritic cells play a pivotal role in the regulation of inflammatory and immune responses. In this lecture, students learn the origin of macrophages and dendritic cells and mechanisms underlying their recruitment to the inflammatory site. Through this lecture, students will understand the potential of macrophages and dendritic cells as a therapeutic target of inflammatory and immune diseases.

授業計画
Class plan

1●Structure and function of the gene: KITAMURA Daisuke
--Students will understand the structure and function of genes in the genome and the major genetic engineering technology.

2●Gene recombination: MIZUTA Ryushin
--Students will understand the mechanism of genetic information reorganization by cutting and repairing DNA. Further, Students will understand the physiological significance of that mechanism.

3●High dimensional structure and Function of Protein: KOZONO Haruo
--Higher-order structure is essential for protein to exert the function. Students will understand the molecular mechanism of antigen recognition with focusing on higher-order structure of the protein to be expressed in the immune system.

4●New imaging technology for life system analysis: NAKANURA Takeshi
--State-of-the-art imaging technology (two-photon excitation microscope, super-resolution microscope, FRET imaging, etc.) is effective for analyzing the life system from molecules to cells and whole animals. Students will be able to understand the fundamentals of the microscope and the outline of these imaging techniques.

5●Epigenetic control in developmental biology: IKAWA Tomokatsu
In differentiation process of stem cells, epigenetic control is necessary switch to read necessary information on the genomic DNA. Students will understand the molecular mechanism of epigenetic regulation, including DNA methylation and histone modification, in cell maintenance and differentiation.

6●Gene regulation and advanced techniques by RNA editing & modifications: SAKURAI Masayuki
RNA transcribed from DNA are known to be composed of four bases; A, G, C and U. However, RNA bases are further modified or edited enzymatically such as inosine produced by deamination of A. Students will understand the mechanisms of RNA editing & modifications known as “epitranscriptomics” and the recent applied techniques for the regulation of gene expression and the cure for diseases.

7●Stem cell biology: GOISUKA Ryo
--Tissue stem cells represented by hematopoietic stem cells are important groups of cells to maintain homeostasis of the living organism. Students will understand the development and maintenance of stem cells, and the relationship of stem cells and the microenvironment.

8●Lineage determination and development of the immune system: NAKANO Naoko
--Students need to understand the molecular mechanism, that is, immune system cells with different function differentiated from hematopoietic stem cells, and lineage decision is taken place.

9●Cell competition and carcinogenesis: KON Shunsuke
--This class starts with general remarks on oncogenesis and tumor progression, and mainly deals with cell competition between normal and transformed epithelial cells.　

10●Animal Disease Models: IWAKURA Yoichiro
--The homeostasis of our body is maintained by the collaboration of many genes as a system. In this lecture, you will learn how cytokines and innate immune receptors are involved in the development of diseases using gene manipulated mouse models.

11●Cytokines and disease; New insight in allergy: KUBO Masato
--Students will understand the mechanism of diseases caused by the dysregulation of cytokines. Also, students will understand the current status of medical care with biologic targeting cytokine function. Moreover, students will understand the molecular basis of many allergic diseases.

12●Regulation of inflammation and immunity by cytokines and chemokines:TERASHIMA Yuya
--Most of the human diseases are inflammatory and immune diseases. Tissue infiltration of specific types of leukocytes underlies the inflammatory and immune responses to invasive stress. In this lecture, students will learn basic mechanisms of the inflammatory and immune responses regulated by cytokines and chemokines, and understand the bases for disease treatments which target cytokines and chemokines.

13●Acquired immune response and signaling: OGAWA Syuuhei
--Students will understand what molecule is activated and transmitted, when the signal is transmitted from antigen receptor, auxiliary signal molecule, and the cytokine receptor. Students will understand what kind of role the activation of each signaling pathway perform for the activation and expression function in T cells and B cells

14●Data science and mathematical modeling in life sciences: HAENO Hiroshi
--Large datasets about DNA mutations, gene expression, and so on have become easily available due to the development of measurement technology. In this lecture, students will learn how to analyze such big data, understand the evolutionary dynamics of tumor progression from initiation to diagnosis, and acquire basic knowledge about immunity as a defense mechanism against non-self organisms.

15●Population dynamics of macrophages and dendritic cells in vivo: UEHA Satoshi
--Macrophages and dendritic cells play a pivotal role in the regulation of inflammatory and immune responses. In this lecture, students learn the origin of macrophages and dendritic cells and mechanisms underlying their recruitment to the inflammatory site. Through this lecture, students will understand the potential of macrophages and dendritic cells as a therapeutic target of inflammatory and immune diseases.　

教職課程 Teacher-training course	This course is related to teacher training and falls into 'a subject originally prepared by the university’ stipulated in the Ordinance for Enforcement of the Education Personnel Certification Act.
実務経験 Practical experience	-
教育用ソフトウェア Educational software	-

備考 Remarks	Note that this course is almost equivalent context to “生命システム論” on Wednesday 5th period in the 2022 First Semester. We recommend to take 生命システム論" instead of this course unless you are not able to understand Japanese at all. "生命システム論" is basically performed in English. *Unless an international student who can not understand Japanese at all selects this course, We will not hold it. Once it is determined to be held, any students can take the course.

備考
Remarks

*Note that this course is almost equivalent context to “生命システム論” on Wednesday 5th period in the 2022 First Semester. We recommend to take 生命システム論" instead of this course unless you are not able to understand Japanese at all. "生命システム論" is basically performed in English.
**Unless an international student who can not understand Japanese at all selects this course, We will not hold it. Once it is determined to be held, any students can take the course.

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